Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction.

@article{Turaga1993FrequencyOB,
  title={Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction.},
  author={P S Turaga and Michael T. Berton and Judy M. Teale},
  journal={Journal of immunology},
  year={1993},
  volume={151 3},
  pages={
          1383-90
        }
}
Murine B cells when activated with LPS and IL-4 have been shown to secrete IgG1 and IgE with corresponding H chain gene rearrangements. Using this system it has been previously demonstrated that transcription of gamma 1 and epsilon C region genes in their germ-line configuration occurs before switch recombination. Here, for the first time, the frequencies of B cells expressing germ-line gamma 1 transcripts are analyzed using in situ hybridization methodology. The results indicate that the… CONTINUE READING