Frequency of B cells committed to the production of antibodies to insulin in newly diagnosed patients with insulin-dependent diabetes mellitus and generation of high affinity human monoclonal IgG to insulin.

Abstract

Circulating autoantibodies to insulin can be detected in patients with insulin-dependent (type I) diabetes mellitus (IDDM) at the onset of the clinical disease. To characterize the autoantibody response in IDDM patients, we determined the frequency of circulating B cells committed to the production of IgM, IgG, and IgA to insulin in 12 newly diagnosed IDDM… (More)

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Cite this paper

@article{Casali1990FrequencyOB, title={Frequency of B cells committed to the production of antibodies to insulin in newly diagnosed patients with insulin-dependent diabetes mellitus and generation of high affinity human monoclonal IgG to insulin.}, author={Paolo Giovanni Casali and M. Nakamura and Fredda V Ginsberg-Fellner and A. L. Notkins}, journal={Journal of immunology}, year={1990}, volume={144 10}, pages={3741-7} }