Frequency modulation of transmitter release

  title={Frequency modulation of transmitter release},
  author={Jean Vautrin and Anne E. Schaffner and B. Fontas and Jeffrey L. Barker},
  journal={Journal of Physiology-Paris},
In 1952 Fatt and Katz recorded at a frog neuromuscular junction while stimulating the nerve and found "... that successive endplate potential responses varied in a step-like manner, corresponding to units of miniature endplate potentials" (J Physiol 117, 109-128). This led them to propose that fast neuromuscular transmission is 'quantal'. Quantal release is now commonly ascribed to a vesicular form of neurosecretion since vesicles have routinely been visualized in presynaptic terminals. The… CONTINUE READING