Frequency domain properties and fundamental limits of buffer-feedback regulation in biochemical systems

@article{Hancock2019FrequencyDP,
  title={Frequency domain properties and fundamental limits of buffer-feedback regulation in biochemical systems},
  author={Edward J. Hancock and Jordan Ang},
  journal={Autom.},
  year={2019},
  volume={103},
  pages={330-336}
}
Feedback regulation in biochemical systems is fundamental to homeostasis, with failure causing disease or death. Recent work has found that cooperation between feedback and buffering---the use of reservoirs of molecules to maintain molecular concentrations---is often critical for biochemical regulation, and that buffering can act as a derivative or lead controller. However, buffering differs from derivative feedback in important ways: it is not typically limited by stability constraints on the… Expand
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