Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain

  title={Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain},
  author={J. M. Rigo and Pascal Legendre},
In vertebrates, most glycinergic inhibitory neurons discharge phasically at a relatively low frequency. Such a pattern of glycine liberation from presynaptic terminals may affect the kinetics of post-synaptic glycine receptors. To examine this influence, we have analyzed the behavior of glycine receptors in response to repetitive stimulation at frequencies at which consecutive outside-out currents did not superimpose (0.5-4 Hz). Neurotransmitter release was mimicked on outside-out patches from… CONTINUE READING
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