Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain.

@article{Rigo2006FrequencydependentMO,
  title={Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain.},
  author={J M Rigo and Pascal Legendre},
  journal={Neuroscience},
  year={2006},
  volume={140 2},
  pages={389-402}
}
In vertebrates, most glycinergic inhibitory neurons discharge phasically at a relatively low frequency. Such a pattern of glycine liberation from presynaptic terminals may affect the kinetics of post-synaptic glycine receptors. To examine this influence, we have analyzed the behavior of glycine receptors in response to repetitive stimulation at frequencies at which consecutive outside-out currents did not superimpose (0.5-4 Hz). Neurotransmitter release was mimicked on outside-out patches from… CONTINUE READING