Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells.

  title={Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells.},
  author={J{\'e}r{\'e}my Fauconnier and Alain Lacampagne and Jean-Michel Rauzier and Pierre Fontanaud and J M Frapier and Ole Mathias Sejersted and Guy Vassort and Sylvain Richard},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={288 2},
FK-506, a widely used immunosuppressant, has caused a few clinical cases with QT prolongation and torsades de pointe at high blood concentration. The proarrhytmogenic potential of FK-506 was investigated in single rat ventricular cells using the whole cell clamp method to record action potentials (APs) and ionic currents. Fluorescence measurements of Ca2+ transients were performed with indo-1 AM using a multiphotonic microscope. FK-506 (25 micromol/l) hyperpolarized the resting membrane… CONTINUE READING


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