Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells.

@article{Mellor1997FrequencydependentAO,
  title={Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells.},
  author={Jack R Mellor and Andrew D Randall},
  journal={The Journal of physiology},
  year={1997},
  volume={503 ( Pt 2)},
  pages={353-69}
}
1. Miniature IPSCs recorded from cultured murine cerebellar granule cells increased in half-width and amplitude following application of the benzodiazepine (BDZ) Flunitrazepam (Flu, 1 microM). The increase in the half-width was much greater than that in the amplitude. 2. Five-millisecond applications of 1 mM GABA to nucleated outside-out patches elicited rapidly rising biexponentially decaying responses that resembled IPSCs. Flu had no effect on the amplitude of such responses, but consistently… CONTINUE READING
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