Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban.

@article{Desantiago2002FrequencydependentAO,
  title={Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban.},
  author={Jaime Desantiago and Lars Siegfried Maier and Donald M. Bers},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 8},
  pages={975-84}
}
Frequency-dependent acceleration of relaxation (FDAR) is an intrinsic physiological mechanism, which allows more rapid ventricular diastolic filling at higher heart rates. FDAR is also observed in isolated myocardial trabeculae and cardiac myocytes, but its mechanism is still poorly understood. We tested the hypothesis that FDAR results mainly from Ca/calmodulin-dependent protein kinase II (CaMKII) dependent stimulation of sarcoplasmic reticulum (SR) Ca transport, but does not require… CONTINUE READING
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