Frequency-dependent acceleration of cardiac repolarization by progesterone underlying its cardiac protection against drug-induced proarrhythmic effects in female rabbits.

  title={Frequency-dependent acceleration of cardiac repolarization by progesterone underlying its cardiac protection against drug-induced proarrhythmic effects in female rabbits.},
  author={Jianhua Cheng and Juan Zhang and Xiaohong Ma and Dan Su},
  journal={European journal of pharmacology},
  volume={689 1-3},
Concurrent supplement of estradiol and progesterone has been shown to reduce the cardiac sensitivity to class III antiarrhythmic agent-induced arrhythmias in ovariectomized rabbits. To understand the underlying cardiac electrophysiological mechanisms of the hormones, present study explored the modulation of progesterone and estradiol on repolarization and its frequency dependence in papillary muscles of female rabbit right ventricles by glass microelectrode technique. Results showed that… Expand
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Concurrent Supplement of Estradiol and Progesterone Reduces the Cardiac Sensitivity to D,L-Sotalol-Induced Arrhythmias in Ovariectomized Rabbits
Estradiol potentiates QTc prolonging effects of d,l-sotalol and increases the susceptibility to d,r-l- sotalol-induced arrhythmias without significantly alteringQTc itself, whereas progesterone may accelerate the process of repolarization and protect the females from drug- induced arrhythias, thus counteracting the effect of estradiol. Expand
Diverse modulating effects of estradiol and progesterone on the monophasic action potential duration in Langendorff‐perfused female rabbit hearts
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A gender-independent proarrhythmic action of 17beta-estradiol in anaesthetized rabbits.
The proarrhythmic effect of acute administration of 17 beta-estradiol in the alpha(1)-adrenoceptor-stimulated anaesthetized rabbit model was independent of gender, indicating that the underlying mechanism differs from that involved in the gender-selective reduction of ischaemia-induced arrhythmias by 17beta-ESTradiol. Expand
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Evidences of the gender‐related differences in cardiac repolarization and the underlying mechanisms in different animal species and human
In healthy postmenopausal women, hormone replacement therapy with estrogen alone usually produced a prolongation of QT interval, while estrogen plus progesterone had no significant effects on QT intervals but reduced QT dispersion, and there are still conflicting data reported. Expand
Female Gender Does Not Influence the Magnitude of Ibutilide-Induced Repolarization Delay and Incidence of Torsades de Pointes in an In Vivo Rabbit Model of the Acquired Long QT Syndrome
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Recent advances in understanding sex differences in cardiac repolarization.
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