Frequency-dependent acceleration of cardiac repolarization by progesterone underlying its cardiac protection against drug-induced proarrhythmic effects in female rabbits.

@article{Cheng2012FrequencydependentAO,
  title={Frequency-dependent acceleration of cardiac repolarization by progesterone underlying its cardiac protection against drug-induced proarrhythmic effects in female rabbits.},
  author={Jianhua Cheng and Juan Zhang and Xiaohong Ma and Dan Su},
  journal={European journal of pharmacology},
  year={2012},
  volume={689 1-3},
  pages={
          172-8
        }
}
Concurrent supplement of estradiol and progesterone has been shown to reduce the cardiac sensitivity to class III antiarrhythmic agent-induced arrhythmias in ovariectomized rabbits. To understand the underlying cardiac electrophysiological mechanisms of the hormones, present study explored the modulation of progesterone and estradiol on repolarization and its frequency dependence in papillary muscles of female rabbit right ventricles by glass microelectrode technique. Results showed that… Expand
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