Frequency and type of colorectal tumors in asymptomatic high-risk individuals in families with hereditary nonpolyposis colorectal cancer.

@article{Leon1998FrequencyAT,
  title={Frequency and type of colorectal tumors in asymptomatic high-risk individuals in families with hereditary nonpolyposis colorectal cancer.},
  author={Maurizio Ponz de Leon and Giacinto Della Casa and Piero Benatti and A. Percesepe and Carmela Di Gregorio and Rossella Fante and Luca Roncucci},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1998},
  volume={7 7},
  pages={639-41}
}
In hereditary nonpolyposis colorectal cancer (HNPCC, or Lynch syndrome) a close surveillance is usually proposed to high-risk family members with the ultimate goal of reducing cancer incidence and mortality. Through a specialized registry, between 1984 and 1996, we identified 31 families with clinical features of HNPCC. A total of 390 first-degree relatives of affected patients were considered at high risk for colorectal cancer. The main purposes of this study were: (a) to assess overall… CONTINUE READING

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Pathology of hereditary nonpolyposis colorectal cancer.

Annals of the New York Academy of Sciences • 2000
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