Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy.

@article{Lima2007FrequencyAP,
  title={Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy.},
  author={Marco Ant{\^o}nio Oliveira Lima and Angela Marzocchetti and Patrick Autissier and Troy Tompkins and Yiping Chen and Jennifer C Gordon and David B Clifford and Rajesh T Gandhi and Nagagopal Venna and Joseph R. Berger and Igor J Koralnik},
  journal={Journal of virology},
  year={2007},
  volume={81 7},
  pages={
          3361-8
        }
}
JC virus (JCV)-specific CD8+ cytotoxic T lymphocytes (CTL) are associated with a favorable outcome in patients with progressive multifocal leukoencephalopathy (PML) and cross-recognize the polyomavirus BK virus (BKV). We sought to determine the frequency and phenotype in fresh blood of CD8+ T cells specific for two A*0201-restricted JCV epitopes, VP1(p36) and VP1(p100), and assess their impact on JC and BK viremia and viruria in 15 healthy subjects, eight human immunodeficiency virus-positive… CONTINUE READING

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