Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma

@article{Greger1994FrequencyAP,
  title={Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma},
  author={Valerie Greger and Nils P Debus and Dietmar Rudolf Lohmann and Wolfgang H{\"o}pping and Eberhard Passarge and Bernhard Horsthemke},
  journal={Human Genetics},
  year={1994},
  volume={94},
  pages={491-496}
}
The retinoblastoma susceptibility (RB1) gene contains an unmethylated CpG-rich island at its 5′ end. Using methylation-sensitive restriction enzymes, we have investigated the methylation status of this island in 21 sporadic unilateral retinoblastomas and 30 hereditary retinoblastomas. Three sporadic unilateral tumors were found to have hypermethylated RB1… CONTINUE READING