Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese.

@article{Heneghan2003FrequencyAN,
  title={Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese.},
  author={Michael A. Heneghan and Philip James Johnson and Michael A Clare and Stephen V Ho and Phillip M. Harrison and Peter T. Donaldson},
  journal={International journal of gastrointestinal cancer},
  year={2003},
  volume={34 1},
  pages={19-26}
}
BACKGROUND The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Genomic DNA was available from 98 patients with HCC, 77 familial controls, 97 controls from Hong Kong and 96 Northern European controls (NECs). METHODS Polymorphisms of interleukin (IL)-1beta; IL-1 receptor antagonist (IL-1RN); IL-10 promoter (positions -1082, -819, and -592); and tumor necrosis factor (TNF)-alpha promoter (TNF-a -238 and -308) were investigated. RESULTS There was marked… CONTINUE READING
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