Frequency and clinical significance of transition zone cancer in prostate cancer screening

  title={Frequency and clinical significance of transition zone cancer in prostate cancer screening},
  author={Andreas Reissigl and Josef Pointner and Hannes Strasser and Othmar Ennemoser and Helmut Klocker and Georg Bartsch},
  journal={The Prostate},
Approximately 20% of prostate cancers originate in the transition zone (TZ). Although transrectal ultrasound (TRUS) and systematic biopsies have improved peripheral zone (PZ) cancer diagnosis, additional biopsies directed into the TZ may further improve cancer detection. 

Differences in biopsy features between prostate cancers located in the transition and peripheral zone

To identify the zonal location of prostate cancers before surgery, by analysing the mapping of ultrasonography‐guided systematic sextant biopsies for differences between cancers located in the

Peripheral zone prostate cancers: Location and intraprostatic patterns of spread at histopathology

To describe the precise location of peripheral zone (PZ) prostate cancers at various stages of development and to demonstrate their pattern of intraprostatic spread from their site of origin.

Transition zone and anterior stromal prostate cancers: Zone of origin and intraprostatic patterns of spread at histopathology

To describe the precise location of transition zone (TZ) and anterior fibromuscular stroma (AFMS) prostate cancers (TZ/AFMS) within histological zones at various stages of development and to

Does transurethral resection of the prostate facilitate detection of clinically significant prostate cancer that is missed with systematic sextant and transition zone biopsies?

Whether transurethral resection of the prostate (TURP) facilitates detection of prostate cancer that is missed with systematic sextantBiopsies associated with transition zone (TZ) biopsies is investigated.

Biochemical recurrence following radical prostatectomy: A comparison between prostate cancers located in different anatomical zones

To assess whether differences of biochemical recurrence after radical prostatectomy exist between prostate cancers located in the transition zone (TZ) and peripheral zone (PZ), the objective is to establish a statistical procedure and show direct comparison between TZ and PZ for prostate cancers.

Analysis of differences in clinicopathological features between prostate cancers located in the transition and peripheral zones

This study retrospectively characterize differences in the clinicopathological features of prostate cancer according to the zonal origin in order to characterize the role of EMT, chemotherapy, and radiation in the development of Prostate cancer.

[Clinicopathological analysis of transition zone cancer of the prostate: the clinical significance of coexistent non-transition zone cancer foci].

It is believed that pre-operative evaluation of non-TZ cancer foci is needed in TZ cancer cases of the candidates for nerve-sparing radical prostatectomy, because ultrasound-guided systematic biopsies have been generalized.

Transition Zone Biopsy in the Detection of Prostate Cancer

Routine TZ biopsy does not substantially increase the prostate cancer detection rate; however, it can be useful in patients who require repeat biopsy.

Prognostic markers in prostate cancer : studies of a watchful waiting cohort with long follow up

The prostate specific antigen (PSA) blood test and histological grading of prostate tissue samples show clear trends in prognosis and aggressive prostate cancer patients are diagnosed with at least two types of cancer.

Prostate cancers in the transition zone: Part 2; clinical aspects

Variation in the definition of TZ cancers is not uniform, which may also explain the varying rate in different series, and should be considered when comparing different studies.



The present status of radical prostatectomy for stages A and B prostatic cancer.

Radical prostatectomy for cure should be limited to clinical B1 cases without distant spread, but it provides the best 15-year survival rate more completely, more quickly, less expensively, and with fewer discomforts than other methods.

Zonal Distribution of Prostatic Adenocarcinoma: Correlation with Histologic Pattern and Direction of Spread

It is concluded that carcinoma typically arises in the region of the prostate that is susceptible to benign prostatic hyperplasia and that the great majority of Stage A (TUR) cancers are transition zone cancers.

Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies

Evaluation of various factors affecting survival and mortality disclosed that an extension of the tumor to seminal vesicles or invasion of the capsule, whether detected clinically or pathologically, had an unfavorable prognosis while the side involved, the location of the tumors, and perineural invasion had no significant effect on the prognosis.

Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges.

The influence of patient age and prostatic size on the serum PSA concentration was assessed in order to use PSA more appropriately to detect clinically significant prostate cancer at an early, potentially curable stage.

The localization of prostatic carcinoma. An autopsy study.

  • I. Liavåg
  • Medicine
    Scandinavian journal of urology and nephrology
  • 1968
The topographical division of the prostate used in this study does not support the opinion held previously, that carcinoma has any site of predilection in the prostate gland, and seems to parallel the amount of glandular tissue in the various areas.