Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.

  title={Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.},
  author={Urs Daniel Lichtenauer and Guido Di Dalmazi and Emily Prentice Slater and Thomas Wieland and Anne Kuebart and Anett Schmittfull and Thomas Schwarzmayr and Susanne Diener and Dominik Wiese and Wolfgang E. Thasler and Martin Reincke and Thomas Meitinger and Matthias Schott and Martin Fassnacht and Detlef Klaus Bartsch and Tim Matthias Strom and Felix Beuschlein},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={100 5},
CONTEXT Insulinomas represent pancreatic neuroendocrine neoplasms that cause severe morbidity attributed to their often pronounced endocrine activity. Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. Applying next-generation sequencing methods, disease-causing genetic alterations have been identified in various endocrine tumors. OBJECTIVE AND DESIGN Paired tumor and blood… CONTINUE READING
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