Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1

@inproceedings{Howard2009FrequencyAE,
  title={Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1},
  author={Susan Julie Howard and Da{\vs}a Cerar and Michael J. Anderson and Ahmed M. Albarrag and Matthew C. Fisher and Alessandro Comar{\'u} Pasqualotto and Mich{\'e}l Laverdi{\`e}re and Maiken Cavling Arendrup and David Scott Perlin and David William Denning},
  booktitle={Emerging infectious diseases},
  year={2009}
}
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, UK. In a clinical collection of 519 A. fumigatus isolates, the frequency of itraconazole resistance was 5%, a significant increase since 2004 (p<0.001). Of the 34 itraconazole-resistant isolates we studied, 65% (22) were cross-resistant to voriconazole and 74% (25) were cross-resistant to posaconazole. Thirteen… CONTINUE READING
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The potential role of Afumdr4 in azole resistance during Aspergillus fumigatus multicellular growth

  • E Mowat, P Warn, D Denning, W Fitzpatrick, T Patterson, B Jones
  • Presented at: 48th Interscience Conference on…
  • 2008
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