Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels.

@article{King1991FrequencyAO,
  title={Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels.},
  author={Chelsea L. King and Robert W. Poindexter and J Ragunathan and Thomas A. Fleisher and Eric A. Ottesen and Thomas B Nutman},
  journal={Journal of immunology},
  year={1991},
  volume={146 5},
  pages={
          1478-83
        }
}
The immunoregulatory mechanisms that determine the high serum IgE antibody levels in disorders such as helminth parasite infections and the hyper-IgE recurrent infection syndrome (HIE) remain poorly understood. To assess whether elevated serum IgE levels result from an increased number of B lymphocytes committed to IgE production, the proportion of IgE-producing B lymphocytes was determined by a filter immunoplaque assay using PBMC from persons with a broad range of serum IgE levels that… CONTINUE READING

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