Frequency Modulation of Hippocampal Theta by the Supramammillary Nucleus, and Other Hypothalamo–Hippocampal Interactions: Mechanisms and Functional Implications

@article{Kirk1998FrequencyMO,
  title={Frequency Modulation of Hippocampal Theta by the Supramammillary Nucleus, and Other Hypothalamo–Hippocampal Interactions: Mechanisms and Functional Implications},
  author={Ian J. Kirk},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1998},
  volume={22},
  pages={291-302}
}
  • I. Kirk
  • Published 1 March 1998
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
In this paper it is argued that theta-range hippocampal EEG activity, and in particular the specific frequency at which it occurs, is critical to hippocampal function. Results of the reviewed studies suggest that in particular circumstances (in the urethane anaesthetized animal and possibly during particular behavioral states), the frequency of hippocampal theta is primarily determined in the supramammillary nucleus (SuM). Rhythmic theta-frequency neuronal activity in the SuM is relayed to, and… Expand
The effect of pharmacological inactivation of the mammillary body and anterior thalamic nuclei on hippocampal theta rhythm in urethane-anesthetized rats
TLDR
It is argued that the MB-ATN axis not only relays theta signal, but may also modulate it, and may be much more important than has been speculated so far in regulating theta rhythm signaling. Expand
The Role of Theta-Range Oscillations in Synchronising and Integrating Activity in Distributed Mnemonic Networks
TLDR
It will be argued that theta-rhythmic activity occurs across distributed networks within the diencephalon and neocortex as well as the hippocampus, and functions to temporally coordinate activity in distributed systems within these regions during mnemonic processes. Expand
Inactivation of the medial mammillary nucleus attenuates theta rhythm activity in the hippocampus in urethane-anesthetized rats
TLDR
It is shown for the first time that inactivation of the medial mammillary nucleus leads to a disruption of hippocampal theta rhythm in the rat, which may suggest that the mammillary body can regulate theTA rhythm signaling in the extended hippocampal system. Expand
The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.
TLDR
A novel role is revealed of the LS, especially its dorsal aspects, as an important gating mechanism for the expression of theta oscillations in the rodent hippocampus, and the fact that dLS-muscimol increased theta frequency while also reducing anxiety-like behaviors challenges the influential theta suppression model of anxiolysis. Expand
The role of the medial supramammillary nucleus in the control of hippocampal theta activity and behaviour in rats
TLDR
The medial supramammillary nucleus (mSUM) function impacts on emotional behaviour more than cognition, and can modulate theta and behaviour independently, suggesting that mSUM function is involved in controlling several hippocampal‐dependent functions. Expand
The effect of intraseptal procaine injection of hippocampal theta in freely moving cat
TLDR
The present data supported the earlier results obtained in the rat and determined that the medial septal region plays a critical role in the generation of the hippocampal theta activity in cat. Expand
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TLDR
It is suggested that the hippocampus receives two main types of input: theta rhythm from ascending brain stem- diencephaloseptal systems and information bearing mainly from thalamocortical/cortical systems. Expand
Frontal-midline theta from the perspective of hippocampal “theta”
TLDR
The hippocampal "theta rhythm" has been extensively studied in rats and its rhythmicity has recently been shown to be functionally significant, per se, and relevant aspects of the hippocampal literature are used to provide perspective on one of the most studied human EEG rhythms: frontal-midline theta. Expand
Possible Mechanisms of the Complex Effects of Acetylcholine on Theta Activity, Learning, and Memory
Disturbances of learning and memory are related to the impaired expression of rhythmic activity and phase synchronization in the hippocampus, entorhinal cortex, and other cortical areas. SeveralExpand
Induction of hippocampal theta rhythm by electrical stimulation of the ventral tegmental area and its loss after septum inactivation
TLDR
The data suggest that the projection through which the VTA enhances theta rhythm is not direct but is incorporated into the main route of theta generation, which involves septum as the main relay node. Expand
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References

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The present report demonstrates that the supramammillary nucleus plays a questionable role in the mediation of hippocampal electroencephalogram signals which are thought to be important for mnemonic processes. Expand
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  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
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TLDR
The foregoing suggests that the theta-related cells of MB are driven by descending projections from the hippocampal formation (CA1), whereas those of the SUM are not, and may be directly involved in the generation of theta and/or the transfer of theTA rhythmicity to various parts of the limbic system and forebrain. Expand
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The results suggest that in freely moving animals SuM is only one of two or more nuclei which jointly control the frequency of reticular‐elicited theta in urethane‐anesthetized rats. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The initial recovery of theta-on cells in the post-procaine condition was correlated with the first appearance of theTA and was characterized by low discharge rates, and three of the dependent measures of hippocampal field activity showed a progressive recovery during the 60-min post- Procaine period. Expand
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