Frequency-Independent Synaptic Transmission Supports a Linear Vestibular Behavior

  title={Frequency-Independent Synaptic Transmission Supports a Linear Vestibular Behavior},
  author={Martha W. Bagnall and Lauren E. McElvain and Michael Faulstich and Sascha du Lac},
The vestibular system is responsible for transforming head motion into precise eye, head, and body movements that rapidly stabilize gaze and posture. How do central excitatory synapses mediate behavioral outputs accurately matched to sensory inputs over a wide dynamic range? Here we demonstrate that vestibular afferent synapses in vitro express frequency-independent transmission that spans their in vivo dynamic range (5-150 spikes/s). As a result, the synaptic charge transfer per unit time is… CONTINUE READING
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