Frequency-Dependent Evaluation of the Role of Definity in Producing Sonoporation of Chinese Hamster Ovary Cells

@article{Forbes2011FrequencyDependentEO,
  title={Frequency-Dependent Evaluation of the Role of Definity in Producing Sonoporation of Chinese Hamster Ovary Cells},
  author={Monica Mary Forbes and Ryan L. Steinberg and William D. O'Brien},
  journal={Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine},
  year={2011},
  volume={30 1},
  pages={
          61-9
        }
}
OBJECTIVES Sonoporation uses ultrasound (US) and ultrasound contrast agents (UCAs) to enhance cell permeabilization, thereby allowing delivery of therapeutic compounds non-invasively into specific target cells. The objective of this study was to elucidate the biophysical mechanism of sonoporation, specifically the role of UCAs as well as exposure frequency. The inertial cavitation (IC) thresholds of the lipid-shelled octafluoropropane UCA were directly compared to the levels of generated… CONTINUE READING

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