Frequencies of Single-Nucleotide Polymorphisms and Mutations in the BRCA1 Gene in Patients with Hereditary Breast or Ovarian Cancer

@article{Karpukhin2002FrequenciesOS,
  title={Frequencies of Single-Nucleotide Polymorphisms and Mutations in the BRCA1 Gene in Patients with Hereditary Breast or Ovarian Cancer},
  author={Alexandr V Karpukhin and N. I. Pospekhova and L. N. Lubchenko and A. N. Loginova and E. V. Khomich and A. V. Budilov and A. S. Sergeev and V. M. Zakhar'ev and R. F. Gar'kavtseva and Evgeny K Ginter},
  journal={Doklady Biological Sciences},
  year={2002},
  volume={383},
  pages={144-146}
}
Mutations in the BRCA1 gene are detected in most cases of hereditary breast or ovarian cancer. The BRCA1 gene is involved in maintaining the integrity of the genome and plays a role in regulation of gene transcription [1, 2]. Mutations can arise against the background of different polymorphisms in the gene structure. The study of single-nucleotide polymorphisms (SNPs) in the BRCA1 gene and of the associated haplotypes may provide new insight into the structural and functional characteristics of… CONTINUE READING

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