Frequencies of Mutations in the Connexin 26 Gene (GJB2) in Two Populations of Iran (Tehran and Tabriz)

@inproceedings{Chaleshtori2005FrequenciesOM,
  title={Frequencies of Mutations in the Connexin 26 Gene (GJB2) in Two Populations of Iran (Tehran and Tabriz)},
  author={Morteza Hashemzadeh Chaleshtori and Laleh Hoghooghi Rad and Meysam Dolati and Roksana Sasanfar and H Pourjafari and Mohsen Ghadami and Dd Farhud},
  year={2005}
}
hearing loss has been considered to be a very heterogeneous disorder, mutations in Gap junction beta 2 (GJB2) gene encoding Connexin 26 (Cx26) protein are the major cause of autosomal recessive and sporadic non-syndromic deafness in many populations. In this study, we have investigated the prevalence of the GJB2 gene mutations using nested PCR pre screening strategy and direct sequencing method. Two hundred and seventy two hearing impaired subjects were studied from 210 families obtained from… CONTINUE READING

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