Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer.

@article{Zhang2011FrequenciesOB,
  title={Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer.},
  author={Shiyu Zhang and Robert Royer and Song Li and John R McLaughlin and Barry Rosen and Harvey A. Risch and Isabel Fan and Linda Bradley and Patricia A. Shaw and Steven A Narod},
  journal={Gynecologic oncology},
  year={2011},
  volume={121 2},
  pages={353-7}
}
BACKGROUND The heritable fraction of ovarian cancer exceeds that of any other common adult cancer. Most inherited cases of ovarian cancer are due to a germline mutation in BRCA1 or BRCA2. It is important to have an accurate estimate of the proportion of ovarian cancer patients who carry a mutation and the specific factors which predict the presence of a mutation. METHODS We tested a population-based series of 1342 unselected patients diagnosed with invasive ovarian cancer between 1995-1999… CONTINUE READING

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