Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia.

@article{Visser2007FrequenciesAR,
  title={Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia.},
  author={Jeroen Visser and Hans W Nijman and B-N Hoogenboom and P. T. Jager and Debbie van Baarle and Ed Schuuring and Wayel H. Abdulahad and Frank A Miedema and Ate G. J. van der Zee and Toos Daemen},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={150 2},
  pages={199-209}
}
Oncogenic human papillomavirus (HPV)-infection is crucial for developing cervical cancer and its precursor lesions [cervical intraepithelial neoplasia (CIN)]. Regulatory T cells (T(regs)) might be involved in the failure of the immune system to control the development of HPV-induced cancer. We investigated frequencies, phenotype and activity of T(regs) in patients with cervical neoplasia. CIN and cervical cancer patients showed increased CD4(+)/CD25(high) T cell frequencies in peripheral blood… CONTINUE READING