French CF family genotype analysis shows that the R297Q mutation is a rare polymorphism.

@article{Dorval1995FrenchCF,
  title={French CF family genotype analysis shows that the R297Q mutation is a rare polymorphism.},
  author={Ian Dorval and Pascal J{\'e}z{\'e}quel and Bruno Chauvel and Christ{\'e}le Dubourg and Patricia Fergelot and Jean Yves Le Gall and Michel Roussey and Martine Blayau},
  journal={Human mutation},
  year={1995},
  volume={6 4},
  pages={334-5}
}
The authors describe a cystic fibrosis family genotype analysis showing that the R297Q amino acid change is a rare polymorphism rather than a deleterious mutation as previously reported. Indeed in this family two healthy subjects have the following genotypes: delta F508/R297Q and N1303K/R297Q.