Freeze-fracture replica immunolabelling reveals caveolin-1 in the human cardiomyocyte plasma membrane

@inproceedings{Robenek2008FreezefractureRI,
  title={Freeze-fracture replica immunolabelling reveals caveolin-1 in the human cardiomyocyte plasma membrane},
  author={Horst Robenek and Gabriele Weissen-Plenz and Nicholas J. Severs},
  booktitle={Journal of cellular and molecular medicine},
  year={2008}
}
Mutations in or ablation of the gene encoding caveolin-3, a protein of muscle cell caveolae, result in forms of muscular dystrophy and cardiomyopathy. Another member of the caveolin gene family, caveolin-1, is widely considered not to be expressed in myocytes, yet ablation of the gene encoding this protein in mice also results in cardiomyopathy. By applying the high-resolution electron-microscopical imaging technique of freeze-fracture replica immunolabelling, we report here evidence that… CONTINUE READING

Citations

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Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction.

  • American journal of physiology. Heart and circulatory physiology
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CITES BACKGROUND

Caveolin-1 exists and may function in cardiomyocytes.

  • Canadian journal of physiology and pharmacology
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