Freeze-fracture electronmicroscopic analysis of plasma membranes of cultured muscle cells in Duchenne dystrophy.


Depletion of intramembranous particles has been reported in the muscle fiber plasma membrane in Duchenne dystrophy. We searched for a similar abnormality in plasma membranes of cultured muscle cells obtained from six patients with Duchenne dystrophy and six controls. A precise method for phase microscopic to freeze-fracture electronmicroscopic correlation… (More)


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