Freeze for action: neurobiological mechanisms in animal and human freezing
@article{Roelofs2017FreezeFA, title={Freeze for action: neurobiological mechanisms in animal and human freezing}, author={Karin Roelofs}, journal={Philosophical Transactions of the Royal Society B: Biological Sciences}, year={2017}, volume={372} }
Upon increasing levels of threat, animals activate qualitatively different defensive modes, including freezing and active fight-or-flight reactions. Whereas freezing is a form of behavioural inhibition accompanied by parasympathetically dominated heart rate deceleration, fight-or-flight reactions are associated with sympathetically driven heart rate acceleration. Despite the potential relevance of freezing for human stress-coping, its phenomenology and neurobiological underpinnings remain…
228 Citations
Human defensive freezing is associated with acute threat coping, long term hair cortisol levels and trait anxiety
- Psychology, BiologybioRxiv
- 2019
The observed links between freezing and subsequent defensive actions as well as predictors of stress-related psychopathology suggest the potential value of defensive freezing reactions as somatic marker for stress-vulnerability and resilience.
Postural freezing relates to startle potentiation in a human fear-conditioning paradigm.
- Psychology, BiologyPsychophysiology
- 2021
It is demonstrated that humans show fear-conditioned animal-like freezing responses, known to aid in active preparation for unexpected attack, and that freezing captures real-life anxiety expression, a promising new, non-invasive, and continuous, readout for human fear conditioning.
Freezing of gaze during action preparation under threat imminence
- Psychology, BiologyScientific Reports
- 2019
Evidence is provided for freezing behavior in measures of visual exploration and it is suggested that such responding is adaptive in preparing the subsequent escape of approaching threats.
Human defensive freezing: Associations with hair cortisol and trait anxiety
- Psychology, BiologyPsychoneuroendocrinology
- 2021
Functional and neural mechanisms of human fear conditioning:studies in healthy and brain-damaged individuals
- Psychology, Biology
- 2020
Evidence reported in this PhD thesis might provide key insights and deeper understanding of critical issues concerning the neurofunctional mechanisms underlying the acquisition, the extinction and the reconsolidation of fear memories in humans.
Approach-Avoidance Decisions Under Threat: The Role of Autonomic Psychophysiological States
- PsychologyFrontiers in Neuroscience
- 2021
A new neurocomputational framework will illustrate how threat-induced bodily states may impact valuation of competing incentives at three stages of the decision-making process, namely at threat evaluation, integration of rewards and threats, and action initiation.
Investigation of the Stability of Human Freezing-Like Responses to Social Threat From Mid to Late Adolescence
- PsychologyFront. Behav. Neurosci.
- 2018
Moderate to strong stability is suggested in human freezing-like behavior in response to social threat from mid to late adolescence (with exception for the body sway measure in males).
Threat imminence modulates neural gain in attention and motor relevant brain circuits in humans.
- Psychology, BiologyPsychophysiology
- 2021
It is shown that healthy humans are characterized by markedly variable individual orienting or defense response tendencies as indexed by differential heart rate (HR) changes during the passive viewing of unpleasant pictures, which predict neural gain modulations in cortical attention and preparatory motor circuits as measured by neuromagnetic steady-state visual evoked fields and induced beta-band desynchronization.
Incident experience predicts freezing-like responses in firefighters
- PsychologyPloS one
- 2017
Findings indicate that higher incident experience relates to decreased threat-induced freezing, at least in a passive task context, and might suggest that primary defense responses are malleable through experience.
References
SHOWING 1-10 OF 144 REFERENCES
Fear bradycardia and activation of the human periaqueductal grey
- Biology, PsychologyNeuroImage
- 2013
Facing Freeze
- PsychologyPsychological science
- 2010
It is found that spontaneous body responses to social threat cues involve freeze-like behavior in humans that mimics animal freeze responses, which open avenues for studying human freeze responses in relation to various sociobiological markers and social-affective disorders.
Fear and the Defense Cascade: Clinical Implications and Management
- Psychology, BiologyHarvard review of psychiatry
- 2015
The process of shifting the neural pattern is the necessary first step in unlocking the patient’s trauma response, in breaking the cycle of suffering, and in helping the patient to adapt to, and overcome, past trauma.
Emotion, motivation, and the brain: reflex foundations in animal and human research.
- Psychology, BiologyProgress in brain research
- 2006
Ready and waiting: Freezing as active action preparation under threat
- Psychology, BiologyNeuroscience Letters
- 2016
The defense system of fear: behavior and neurocircuitry
- Psychology, BiologyNeurophysiologie Clinique/Clinical Neurophysiology
- 2003
From Threat to Fear: The Neural Organization of Defensive Fear Systems in Humans
- Psychology, BiologyThe Journal of Neuroscience
- 2009
These findings support models suggesting that higher forebrain areas are involved in early-threat responses, including the assignment and control of fear, whereas imminent danger results in fast, likely “hard-wired,” defensive reactions mediated by the midbrain.
Parallel circuits mediating distinct emotional coping reactions to different types of stress
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2001
Aversive life events enhance human freezing responses.
- PsychologyJournal of experimental psychology. General
- 2012
The results indicate that aversive life events affect automatic freezing responses and may indicate the cumulative effect of multiple trauma.