Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA.

@article{Furst2016FreezedriedMP,
  title={Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA.},
  author={Tania Furst and George R. Dakwar and Elisa Zagato and Anna Lechanteur and Katrien Remaut and Brigitte Evrard and Kevin Braeckmans and G{\'e}raldine Piel},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={236},
  pages={
          68-78
        }
}
  • T. Furst, George R. Dakwar, +5 authors G. Piel
  • Published 2016
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
Topical vaginal sustained delivery of siRNA presents a significant challenge due to the short residence time of formulations. Therefore, a drug delivery system capable to adhere to the vaginal mucosa is desirable, as it could allow a prolonged delivery and increase the effectiveness of the therapy. The aim of this project is to develop a polymeric solid mucoadhesive system, loaded with lipoplexes, able to be progressively rehydrated by the vaginal fluids to form a hydrogel and to deliver siRNA… Expand
Surface‐modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis
  • F. Kenechukwu, A. Attama, +7 authors P. Akpa
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2018
ABSTRACT The use of conventional vaginal formulations of miconazole nitrate (MN) in the treatment of deep‐seated VVC (vulvovaginal candidiasis) is limited by poor penetration capacity and lowExpand
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