Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer

@article{Tang2005FreezeDryingPD,
  title={Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer},
  author={Xiaolin Charlie Tang and Steven L. Nail and Michael J. Pikal},
  journal={Pharmaceutical Research},
  year={2005},
  volume={22},
  pages={685-700}
}
To develop a procedure based on manometric temperature measurement (MTM) and an “expert system” for good practices in freeze drying that will allow development of an optimized freeze-drying process during a single laboratory freeze-drying experiment. Freeze drying was performed with a FTS Dura-Stop/Dura-Top freeze dryer with the manometric temperature measurement software installed. Five percent solutions of glycine, sucrose, or mannitol with 2 ml to 4 ml fill in 5 ml vials were used, with all… CONTINUE READING