Freeform fabricated scaffolds with roughened struts that enhance both stem cell proliferation and differentiation by controlling cell shape.

@article{Kumar2012FreeformFS,
  title={Freeform fabricated scaffolds with roughened struts that enhance both stem cell proliferation and differentiation by controlling cell shape.},
  author={Girish Kumar and Michael S Waters and Tanya M Farooque and Marian Frances Young and Carl G. Simon},
  journal={Biomaterials},
  year={2012},
  volume={33 16},
  pages={4022-30}
}
We demonstrate that freeform fabricated (FFF) scaffolds with a roughened surface topography can support hBMSC proliferation, while also inducing osteogenic differentiation, for maximized generation of calcified, bone-like tissue. Previously, hBMSCs rapidly proliferated, without osteogenic differentiation, during culture in FFF scaffolds. In contrast, hBMSCs underwent osteogenic differentiation, with slow proliferation, during culture in nanofiber scaffolds. Analysis of cell morphology showed… CONTINUE READING

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