FreeContact: fast and free software for protein contact prediction from residue co-evolution

@inproceedings{Kajn2013FreeContactFA,
  title={FreeContact: fast and free software for protein contact prediction from residue co-evolution},
  author={L{\'a}szl{\'o} Kaj{\'a}n and Thomas A. Hopf and Mat{\'u} Kala and Debora S. Marks and Burkhard Rost},
  booktitle={BMC Bioinformatics},
  year={2013}
}
20 years of improved technology and growing sequences now renders residue-residue contact constraints in large protein families through correlated mutations accurate enough to drive de novo predictions of protein three-dimensional structure. The method EVfold broke new ground using mean-field Direct Coupling Analysis (EVfold-mfDCA); the method PSICOV applied a related concept by estimating a sparse inverse covariance matrix. Both methods (EVfold-mfDCA and PSICOV) are publicly available, but… CONTINUE READING