Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function

@article{Hasselmo1997FreeRA,
  title={Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function},
  author={M. Hasselmo and B. Wyble},
  journal={Behavioural Brain Research},
  year={1997},
  volume={89},
  pages={1-34}
}
  • M. Hasselmo, B. Wyble
  • Published 1997
  • Psychology, Medicine
  • Behavioural Brain Research
  • Free recall and recognition are simulated in a network model of the hippocampal formation, incorporating simplified simulations of neurons, synaptic connections, and the effects of acetylcholine. Simulations focus on modeling the effects of the acetylcholine receptor blocker scopolamine on human memory. Systemic administration of scopolamine is modeled by blockade of the cellular effects of acetylcholine in the model, resulting in memory impairments replicating data from studies on human… CONTINUE READING
    301 Citations
    Neuromodulation and the hippocampus: memory function and dysfunction in a network simulation.
    • 40
    A Mismatch-Based Model for Memory Reconsolidation and Extinction in Attractor Networks
    • 59
    • PDF
    Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model
    • 14
    • Highly Influenced
    • PDF
    Neural Network Model of Memory Retrieval
    • 21
    • PDF
    Integrating incremental learning and episodic memory models of the hippocampal region.
    • 54
    • Highly Influenced
    • PDF
    Memory influences on hippocampal and striatal neural codes: Effects of a shift between task rules
    • 52
    • PDF
    High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation.
    • 483
    • PDF

    References

    SHOWING 1-10 OF 165 REFERENCES
    Acetylcholine and Learning in a Cortical Associative Memory
    • M. Hasselmo
    • Psychology, Computer Science
    • Neural Computation
    • 1993
    • 106
    Recall and Recognition in an Attractor Neural Network Model of Memory Retrieval
    • 17
    • PDF
    Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology
    • M. Hasselmo, E. Schnell
    • Chemistry, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1994
    • 421
    • PDF
    Cholinergic modulation of cortical associative memory function.
    • 230
    Simulation studies of the CA3 hippocampal subfield modelled as an attractor neural network
    • 69
    Hippocampal synaptic enhancement and information storage within a distributed memory system
    • 1,172
    Acetylcholine and memory
    • 387
    Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3
    • 447
    • PDF