Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function

  title={Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function},
  author={M. Hasselmo and B. Wyble},
  journal={Behavioural Brain Research},
  • M. Hasselmo, B. Wyble
  • Published 1997
  • Psychology, Medicine
  • Behavioural Brain Research
  • Free recall and recognition are simulated in a network model of the hippocampal formation, incorporating simplified simulations of neurons, synaptic connections, and the effects of acetylcholine. Simulations focus on modeling the effects of the acetylcholine receptor blocker scopolamine on human memory. Systemic administration of scopolamine is modeled by blockade of the cellular effects of acetylcholine in the model, resulting in memory impairments replicating data from studies on human… CONTINUE READING
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