Free reactive oxygen species and nephrotoxicity of contrast agents.

@article{Haeussler2004FreeRO,
  title={Free reactive oxygen species and nephrotoxicity of contrast agents.},
  author={Ulla Haeussler and Martin Riedel and Frieder Keller},
  journal={Kidney & blood pressure research},
  year={2004},
  volume={27 3},
  pages={167-71}
}
BACKGROUND The nephrotoxicity induced by contrast media remains a serious clinical problem, and the underlying mechanism has not been completely understood. Experimental and clinical investigations suggest that reactive oxygen species (ROS) are critical determinants of radiocontrast nephropathy (RCN), and that antioxidants can prevent this damage. METHODS Cultured human proximal renal tubule cells (HK-2) were exposed to hydrogen peroxide (H2O2) at different concentrations. H2O2-induced… CONTINUE READING

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Furosemide after contrast media does no harm to the kidneys and allows for preventive hydration

  • R Lukas, A Eren, +4 authors F Keller
  • Perfusion
  • 2003

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