Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects.

@article{Chen2005FreeRT,
  title={Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects.},
  author={Jian-Wen Chen and Kurt H\ojlund and Henning Beck-Nielsen and Jens Sandahl Christiansen and Hans Orskov and Jan Frystyk},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 1},
  pages={366-71}
}
Pituitary GH secretion is feedback regulated by circulating IGF-I. However, it remains to be determined whether the feedback control is mediated through circulating free or total IGF-I. To study this, we compared the temporal changes in circulating levels of GH vs. free and total IGF-I during fasting. Seventeen healthy normal-weight subjects (body mass index 23.4 +/- 0.6 kg/m(2)) were studied during 80 h of fasting. Serum was assayed for GH every 3 h; total, free, and bioactive IGF-I, IGF… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants.

American journal of physiology. Endocrinology and metabolism • 2007
View 4 Excerpts
Highly Influenced

Effects of insulin-like growth factor-I administration on in vivo regulation of urea synthesis in normal subjects and patients with cirrhosis.

Liver international : official journal of the International Association for the Study of the Liver • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…