Free radicals upregulate complement expression in rabbit isolated heart.

@article{Tanhehco2000FreeRU,
  title={Free radicals upregulate complement expression in rabbit isolated heart.},
  author={Elaine J. Tanhehco and Koji Yasojima and Patrick L. Mcgeer and Ruth A Washington and Benedict Robert Lucchesi},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 1},
  pages={H195-201}
}
Both free radicals and complement activation can injure tissue. Our study determined whether free radicals alter complement production by the myocardium. Isolated hearts from New Zealand White rabbits were perfused on a Langendorff apparatus and exposed to xanthine (X; 100 microM) plus xanthine oxidase (XO; 8 mU/ml) (X/XO). The free radical-generating system significantly (P < 0.05) increased C1q and also increased C1r, C3, C8, and C9 transcription compared with controls. Immunohistological… CONTINUE READING

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