Free radicals in inflammatory bowel diseases pathophysiology and therapeutic implications.

@article{Gro1994FreeRI,
  title={Free radicals in inflammatory bowel diseases pathophysiology and therapeutic implications.},
  author={Volker Gro\ss and Holger Arndt and Tilo Andus and Klaus Dieter Palitzsch and Juergen Schoelmerich},
  journal={Hepato-gastroenterology},
  year={1994},
  volume={41 4},
  pages={320-7}
}
Inflammatory bowel diseases are characterized by the accumulation of granulocytes and monocytes/macrophages at the site of inflammation. Activation of these cells leads to the release of degradative enzymes, e.g., proteinases and glycosidases, and the production of reactive oxygen metabolites. This has been shown both in animal models of experimental intestinal injury, and in human inflammatory bowel disease. Scavenging of oxygen radicals protected tissue from damage in experimental… CONTINUE READING