Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus.

Abstract

NMDA receptor-mediated calcium over-loading and the following free radical generation play essential roles in cerebral ischemia lesion, leading to neuronal cell apoptosis or necrosis through complicated intracellular signaling cascades. Here we evaluated the effects of NMDA receptor antagonist (ketamine) and antioxidant (N-acetylcysteine) on ischemia- and… (More)

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