Free radicals and cardioplegia: allopurinol and oxypurinol reduce myocardial injury following ischemic arrest.

@article{Chambers1987FreeRA,
  title={Free radicals and cardioplegia: allopurinol and oxypurinol reduce myocardial injury following ischemic arrest.},
  author={David John Chambers and M. V. Braimbridge and David J. Hearse},
  journal={The Annals of thoracic surgery},
  year={1987},
  volume={44 3},
  pages={291-7}
}
Oxygen-derived free radicals generated by xanthine oxidase may represent a major cause of myocardial injury during ischemia and reperfusion. We have used the isolated working rat heart model of cardiopulmonary bypass and ischemic arrest to assess whether allopurinol or oxypurinol, which should prevent free radical formation through their ability to inhibit… CONTINUE READING