Free radicals, oxidative stress, and antioxidants in human health and disease

@article{Aruoma1998FreeRO,
  title={Free radicals, oxidative stress, and antioxidants in human health and disease},
  author={O. Aruoma},
  journal={Journal of the American Oil Chemists' Society},
  year={1998},
  volume={75},
  pages={199 - 212}
}
  • O. Aruoma
  • Published 1998
  • Medicine, Chemistry
  • Journal of the American Oil Chemists' Society
    • Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body. Free-radical mechanisms have been implicated in the pathology of several human diseases, including cancer, atherosclerosis, malaria, and rheumatoid arthritis and neurodegenerative diseases. For example, the superoxide radical (O2·−) and hydrogen peroxide (H2O2) are known to be generated in the brain and nervous system in vivo, and several areas of the human brain are rich in iron, which appears to be… CONTINUE READING
    View on Springer
    europepmc.org
    1,387 Citations
    Highly Influential Citations
    48
    Background Citations
    563
    Methods Citations
    18
    Results Citations
    5

    Tables and Topics from this paper

    Tables

    Explore Further: Topics Discussed in This Paper

    1,387 Citations
    Citation Type

    Citation Type

    Oxidative Stress in Aging
    • 53
    • PDF
    Reactive Oxygen Species and Cellular Defense System
    • 59
    • PDF
    Redox state and health: a persisting challenge
    • 2
    Reactive Oxygen Species, Cellular Redox Homeostasis and Cancer
    • 3
    • PDF
    Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
    • 686
    Free radicals, antioxidants, and nutrition.
    • 2,055
    The role of antioxidants in the chemistry of oxidative stress: A review.
    • 784
    Battle between plants as antioxidants with free radicals in human body
    • 5
    • PDF
    Free radicals: health implications and their mitigation by herbals.
    • 35
    The Roles and Mechanisms of ROS, Oxidative Stress, and Oxidative Damage

    References

    SHOWING 1-10 OF 246 REFERENCES
    Human disease, free radicals, and the oxidant/antioxidant balance.
    • J. McCord
    • Chemistry, Medicine
    • Clinical biochemistry
    • 1993
    • 362
    Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA.
    • 242
    Antioxidants in human health and disease.
    • B. Halliwell
    • Chemistry, Medicine
    • Annual review of nutrition
    • 1996
    • 1,706
    Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans.
    • 574
    Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion.
    • 285
    Biochemistry and pathology of radical-mediated protein oxidation.
    • 1,535
    • PDF
    Prooxidant states and tumor promotion.
    • 2,482
    Oxygen-derived species: their relation to human disease and environmental stress.
    • 603
    • PDF
    Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants.
    • 111
    • PDF
    Role of free radicals and catalytic metal ions in human disease: an overview.
    • 4,811