Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics.

@article{Wilson2002FreeRA,
  title={Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics.},
  author={John X. Wilson and Adrian W. Gelb},
  journal={Journal of neurosurgical anesthesiology},
  year={2002},
  volume={14 1},
  pages={66-79}
}
Oxygen-centered free radicals cause brain injury associated with trauma and stroke. These reactive oxygen species may be detoxified by endogenous antioxidants, but cell death occurs after antioxidants become depleted. General anesthetics penetrate into brain parenchyma, where they may abrogate oxidative injury to neurons by several mechanisms that prevent the initiation of free radical chain reactions or terminate the propagation of highly reactive radicals. First, general anesthetics may… CONTINUE READING

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