Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.

@article{McCormick2006FreeRS,
  title={Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.},
  author={James McCormick and Se{\'a}n P. Barry and Ahila Sivarajah and Giorgio Stefanutti and Paul A. Townsend and K. Mark Lawrence and Simon Eaton and Richard A Knight and Christoph Thiemermann and D. S. Latchman and Anastasis Stephanou},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 12},
  pages={2115-7}
}
The signal transducer and activator of transcription (STAT) family are latent transcription factors involved in a variety of signal transduction pathways, including cell death cascades. STAT1 has been shown to have a crucial role in regulating cardiac cell apoptosis in the myocardium exposed to ischemia/reperfusion (I/R) injury. The free radical scavenger, tempol, is known to have cardioprotective properties, although little is known about the molecular mechanism(s) by which it acts. In the… CONTINUE READING

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