Free radical scavengers in mercuric chloride-induced acute renal failure in the rat.

@article{Paller1985FreeRS,
  title={Free radical scavengers in mercuric chloride-induced acute renal failure in the rat.},
  author={Mark S Paller},
  journal={The Journal of laboratory and clinical medicine},
  year={1985},
  volume={105 4},
  pages={459-63}
}
  • Mark S Paller
  • Published 1985 in The Journal of laboratory and clinical medicine
Oxygen free radicals have recently been found to mediate cell injury after ischemia in the kidney. We sought to determine whether oxygen free radicals mediate damage in mercuric chloride (HgCl2)-induced acute renal failure, a toxic model of acute renal failure. Neither superoxide dismutase nor allopurinol, which scavenges or inhibits production of superoxide radical, respectively, provided protection against renal dysfunction after HgCl2. Similarly, the hydroxyl radical scavengers tryptophan, N… CONTINUE READING

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