Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease.

@article{Schneich2003FreeRR,
  title={Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease.},
  author={Christian Sch{\"o}neich and Dariusz Pogocki and Gordon L. Hug and Krzysztof Bobrowski},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 45},
  pages={13700-13}
}
The pathogenesis of Alzheimer's disease is strongly associated with the formation and deposition of beta-amyloid peptide (beta AP) in the brain. This peptide contains a methionine (Met) residue in the C-terminal domain, which is important for its neurotoxicity and its propensity to reduce transition metals and to form reactive oxygen species. Theoretical studies have proposed the formation of beta AP Met radical cations as intermediates, but no experimental evidence with regard to formation and… CONTINUE READING

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