Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts.

@article{Eddy1987FreeRE,
  title={Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts.},
  author={L J Eddy and J R Stewart and Harold P. Jones and Todd Engerson and J M Mccord and James M. Downey},
  journal={The American journal of physiology},
  year={1987},
  volume={253 3 Pt 2},
  pages={H709-11}
}
Samples from four human hearts were analyzed for both their xanthine dehydrogenase and xanthine oxidase content. We used the conventional spectrophotometric assay and a more sensitive fluorometric assay to determine the content of enzyme in these samples. In no case could any activity be detected. We conclude that human hearts must contain less than 2.0 nU/g of activity. This makes it unlikely that xanthine oxidase is a significant source of O2 free radicals in the ischemic human heart or that… CONTINUE READING

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