Free radical-induced damage to DNA: mechanisms and measurement.

@article{Dizdarolu2002FreeRD,
  title={Free radical-induced damage to DNA: mechanisms and measurement.},
  author={Miral Dizdaroğlu and Pawel Jaruga and Mustafa Birincioğlu and Henry Rodriguez},
  journal={Free radical biology & medicine},
  year={2002},
  volume={32 11},
  pages={1102-15}
}
Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells, including DNA. The resulting damage to DNA, which is also called oxidative damage to DNA, is implicated in mutagenesis, carcinogenesis, and aging. Mechanisms of damage involve abstractions and addition reactions by free radicals leading to carbon-centered sugar radicals and OH- or H-adduct radicals of heterocyclic bases. Further reactions of these radicals yield… CONTINUE READING
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