Free radical generation by redox cycling of estrogens.

@article{Liehr1990FreeRG,
  title={Free radical generation by redox cycling of estrogens.},
  author={J. Liehr and D. Roy},
  journal={Free radical biology \& medicine},
  year={1990},
  volume={8 4},
  pages={
          415-23
        }
}
  • J. Liehr, D. Roy
  • Published 1990
  • Chemistry, Medicine
  • Free radical biology & medicine
Natural and synthetic estrogens elicit normal hormonal responses in concentrations in a clearly defined yet low range. At elevated doses, metabolic reactions of the phenolic moiety, while harmless at low levels, may become the predominant biochemical activity and may exert deleterious effects. These metabolic pathways, such as i) oxidation of estrogens to catechol estrogens and further to their respective quinones, and ii) free radical generation by redox cycling between catechol estrogens or… Expand
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