Free-operant and auto-titration brain self-stimulation procedures in the rat: a comparison of drug effects.

@article{Schaefer1979FreeoperantAA,
  title={Free-operant and auto-titration brain self-stimulation procedures in the rat: a comparison of drug effects.},
  author={Gerald J. Schaefer and Stephen G. Holtzman},
  journal={Pharmacology, biochemistry, and behavior},
  year={1979},
  volume={10 1},
  pages={127-35}
}
Rats were implanted with bipolar stimulating electrodes aimed at the medial forebrain bundle of the lateral hypothalamus, and trained to press a lever in one of two different procedures in order to receive electrical stimulation through the electrodes. In a free-operant procedure, each response produced a 200 msec train of electric pulses at a suprathreshold current, the intensity of which remained constant throughout the session. In an auto-titration procedure, each response produced an… CONTINUE READING