Free light chains and the risk of AIDS-defining opportunistic infections in HIV-infected individuals.

@article{Shiels2012FreeLC,
  title={Free light chains and the risk of AIDS-defining opportunistic infections in HIV-infected individuals.},
  author={Meredith S. Shiels and Ola Landgren and Rene Costello and Adriana Zingone and James J Goedert and E. A. N. Engels},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2012},
  volume={55 10},
  pages={e103-8}
}
BACKGROUND The relevance of B-cell dysfunction for progression to AIDS among human immunodeficiency virus (HIV)-infected individuals has not been clearly defined. We evaluated the association between circulating κ and λ free light chains (FLCs), which are markers of B-cell dysfunction, and risk of developing an AIDS-defining opportunistic infection in HIV-infected men. METHODS The study included 252 case patients with clinical AIDS and 252 HIV-infected controls from the Multicenter Hemophilia… CONTINUE READING
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